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KMID : 0854720060260020115
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Korean Journal of Asthma, Allergy and Clinical Immunology
2006 Volume.26 No. 2 p.115 ~ p.121
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Association of Polymorphism in the Promoter Area of Leukotriene C4 Synthase Gene with Aspirin-Intolerant Asthma
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Kim Sang-Heon
Park Heung-Woo
Sohn Seong-Wook
Lee Sang-Min
Oh Sun-Young
Kim Sun-Sin
Bahn Joon-Woo
Chang Yoon-Seok
Shin Eun-Soon
Lee Jong-Eun
Kim Yoon-Keun
Cho Sang-Heon
Min Kyung-Up
Kim You-Young
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Abstract
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Background: The 5-lipoxygenase, 5-lipoxygenase associated protein and leukotriene C4 (LTC4) synthase are enzymes involved in the synthesis of cysteinyl leukotrienes which are known to be important lipid mediators for the development of aspirin-intolerant asthma (AIA). Several studies have evaluated genetic association between polymorphisms of these enzymes and AIA, reporting inconsistent results.
Objective: To evaluate the genetic effect of polymorphisms of promoter areas of ALOX5, ALOX5AP and LTC4S genes in the development of AIA.
Methods: Polymorphisms in promoter areas of ALOX5 (-1761G >A, -1708G>A), ALOX5AP (21A/18A repeat) and LTC4S (-444A>C) were genotyped in patients with AIA (n=44), aspirin-tolerant asthma (ATA, n=104), and healthy-normal controls (NC, n=107).
Results: The frequency of LTC4S -444 AC or CC alleles was significantly lower in AIA patients than in ATA patients (19.0% vs. 36.5%, P=0.005, OR=0.23, 95%CI 0.08~0.64). However, the frequency of these genotypes was not different between AIA and NC (19.0% vs. 24.8%, P=0.458). As to LOX5 -1761G>A, -1708G>A, and ALOX5AP 21A/18A repeat, the frequency of these genotypes was not different between AIA and ATA patients and between AIA and NC.
Conclusion: A significant association was found between LTC4S -444A>C and the frequency of AIA. This finding suggests that LTC4 synthase may be involved in the development of AIA in the Korean population.
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KEYWORD
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ALOX5, ALOX5AP, LTC4S, Asthma, Aspirin-Intolerant Asthma
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